Conditioning- and time-dependent increases in context fear and generalization.

  title={Conditioning- and time-dependent increases in context fear and generalization.},
  author={Andrew M Poulos and Nehali Mehta and Bryan Tran Lu and Dorsa Amir and Briana Livingston and Anthony J Santarelli and Irina Zhuravka and Michael S Fanselow},
  journal={Learning & memory},
  volume={23 7},
A prominent feature of fear memories and anxiety disorders is that they endure across extended periods of time. Here, we examine how the severity of the initial fear experience influences incubation, generalization, and sensitization of contextual fear memories across time. Adult rats were presented with either five, two, one, or zero shocks (1.2 mA, 2 sec) during contextual fear conditioning. Following a recent (1 d) or remote (28 d) retention interval all subjects were returned to the… CONTINUE READING
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