Conditioned tolerance to the anorectic and corticosterone-elevating effects of nicotine

@article{Caggiula1991ConditionedTT,
  title={Conditioned tolerance to the anorectic and corticosterone-elevating effects of nicotine},
  author={Anthony R. Caggiula and Leonard H Epstein and Seymour M. Antelman and Saundra S. Saylor and Richard Stiller},
  journal={Pharmacology Biochemistry and Behavior},
  year={1991},
  volume={40},
  pages={53-59}
}
We have shown that tolerance to the behavioral effects of nicotine is partially dependent on conditioned environmental cues that predict drug delivery. The present research extends this finding to physiological effects of nicotine by assessing both the appetite-suppressing and adrenocortical-activating effects of nicotine, as measured by plasma corticosterone (CORT). In the first study, male rats on a 22-h food deprivation schedule were injected daily with 0.33 or 0.66 mg/kg (free base) of… CONTINUE READING

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