Conditioned stimulus-induced reinstatement of extinguished cocaine seeking in C57BL/6 mice: a mouse model of drug relapse.

@article{Fuchs2003ConditionedSR,
  title={Conditioned stimulus-induced reinstatement of extinguished cocaine seeking in C57BL/6 mice: a mouse model of drug relapse.},
  author={Rita A. Fuchs and Ronald Eugene See and Lawrence D. Middaugh},
  journal={Brain research},
  year={2003},
  volume={973 1},
  pages={99-106}
}
The scarcity of mouse models for relapse to cocaine seeking has curtailed the study of genetic factors that may contribute to susceptibility for drug relapse. To contribute to the development of a new mouse model of drug relapse, C57BL/6 (B6) mice were trained to press a lever for infusions of cocaine (0.35 mg/kg, i.v.) on a fixed ratio 1 schedule of reinforcement during daily 2-h sessions. A light+tone stimulus complex was presented simultaneously with each cocaine infusion. Mice then… CONTINUE READING

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