Conditioned place preference paradigm: a novel approach for analgesic drug assessment against chronic pain.

@article{Sufka1994ConditionedPP,
  title={Conditioned place preference paradigm: a novel approach for analgesic drug assessment against chronic pain.},
  author={Kenneth J. Sufka},
  journal={Pain},
  year={1994},
  volume={58 3},
  pages={355-66}
}
In response to concerns over the clinical relevance of analgesic testing paradigms which involve acute nociceptive stimuli, the present research examined the utility of the conditioned place preference (CPP) paradigm as a novel approach for determination of analgesic drug efficacy against chronic nociception. Rats display preferences for environments that have been previously paired with positively reinforcing drugs; whether place preference to the negatively reinforcing effects of analgesic… CONTINUE READING
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