Conditioned place aversion and self-administration of nitrous oxide in rats

@article{Ramsay2003ConditionedPA,
  title={Conditioned place aversion and self-administration of nitrous oxide in rats},
  author={D. Ramsay and C. H. Watson and B. Leroux and C. Prall and K. Kaiyala},
  journal={Pharmacology Biochemistry and Behavior},
  year={2003},
  volume={74},
  pages={623-633}
}
The rewarding/aversive effects of nitrous oxide (N(2)O) were evaluated using the place conditioning paradigm. Male Long-Evans rats (N=103) received a daily 40-min gas exposure for 8 consecutive days that alternated between two distinct chambers. A control group received placebo gas in both chamber types, while the N(2)O groups (8%, 15%, 30%, and 60% N(2)O) received four consistent pairings of N(2)O with one chamber type and four pairings of placebo gas with the other. A conditioned place… Expand
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