Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems.

Abstract

Withdrawal from nicotine decreases the activity of brain reward systems, measured in rats by elevations of intracranial self-stimulation (ICSS) thresholds. This reward deficit is hypothesized to contribute to the persistence of the tobacco habit in tobacco smokers. Accumulating evidence suggests that aspects of drug withdrawal may become conditioned to… (More)

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@article{Kenny2005ConditionedNW, title={Conditioned nicotine withdrawal profoundly decreases the activity of brain reward systems.}, author={Paul J. Kenny and Athina Markou}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2005}, volume={25 26}, pages={6208-12} }