Conditioned medium from hypoxia-treated adipocytes renders muscle cells insulin resistant.

Abstract

Adipose tissue hypoxia is an early phenotype in obesity, associated with macrophage infiltration and local inflammation. Here we test the hypothesis that adipocytes in culture respond to a hypoxic environment with the release of pro-inflammatory factors that stimulate macrophage migration and cause muscle insulin resistance. 3T3-L1 adipocytes cultured in a… (More)
DOI: 10.1016/j.ejcb.2011.06.004

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Cite this paper

@article{Yu2011ConditionedMF, title={Conditioned medium from hypoxia-treated adipocytes renders muscle cells insulin resistant.}, author={Junna Yu and Lihuan Shi and Hui Wang and Philip J. Bilan and Zhi Yao and M Constantine Samaan and Qing He and A. W. J. Klip and Wen-yan Niu}, journal={European journal of cell biology}, year={2011}, volume={90 12}, pages={1000-15} }