Conditioned medium from bone marrow mesenchymal stem cells transiently retards osteoblast differentiation by downregulating runx2.

@article{Sun2012ConditionedMF,
  title={Conditioned medium from bone marrow mesenchymal stem cells transiently retards osteoblast differentiation by downregulating runx2.},
  author={Jing Sun and Huifang Zhou and Yuan Deng and Yidan Zhang and Ping Gu and Shengfang Ge and Xianqun Fan},
  journal={Cells, tissues, organs},
  year={2012},
  volume={196 6},
  pages={510-22}
}
Mesenchymal stem cells (MSCs) are attractive candidates for cell therapy and regenerative medicine because of their potential for proliferation and multilineage differentiation. MSCs secrete various cytokines, acting as trophic mediators to regulate neighboring cells. Osteoblasts are the cells directly responsible for forming new bone, and they are the final target of many osteogenic regulators. However, the induction effect of MSCs on osteoblasts is still unknown. In this study, we isolated… CONTINUE READING
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