Conditioned Enhancement of Antibody Production Is Disrupted by Insular Cortex and Amygdala but Not Hippocampal Lesions

@article{RamirezAmaya1999ConditionedEO,
  title={Conditioned Enhancement of Antibody Production Is Disrupted by Insular Cortex and Amygdala but Not Hippocampal Lesions},
  author={Victor Ramirez-Amaya and Federico Berm{\'u}dez-Rattoni},
  journal={Brain, Behavior, and Immunity},
  year={1999},
  volume={13},
  pages={46-60}
}
Pavlovian conditioning procedures can be used to activate the immune system. A reliable conditioned increase of antibody production can be obtained in rats that have previously received a gustative or odor stimulus as the conditioned stimulus paired with an antigen, by exposing the animals to the conditioned stimulus alone. We showed evidence that an excitotoxic lesion bilaterally applied into the insular cortex or the amygdala, but not into the dorsal hippocampus, impaired the acquisition of… Expand
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References

SHOWING 1-10 OF 41 REFERENCES
Insular Cortex Lesions Impair the Acquisition of Conditioned Immunosuppression
TLDR
Results show that the insular cortex is essential for the acquisition of conditioned immunosuppression, and NMDA-induced lesions did not affect the normal immune response, showing normal hemagglutinating titers and IgM production when compared to nonconditioned controls. Expand
Differential Effects of NMDA-Induced Lesions into the Insular Cortex and Amygdala on the Acquisition and Evocation of Conditioned Immunosuppression
TLDR
The results of this work suggest that the IC is involved in the neural mechanisms underlying the acquisition and evocation of conditioned immunosuppression, and the amygdala could be important in mediating the input of the immune information necessary for the acquisition of conditioned immunity. Expand
Lesions of the hippocampus enhance or depress humoral immunity in rats.
TLDR
The results suggest that different areas of the hippocampus can stimulate or inhibit humoral immunity, and chemical destruction of pyramidal cell bodies in CA2 and CA3 significantly increased humoral immune as measured by HC50, but larger chemical lesions that also included CA1 did not. Expand
Effects of catecholaminergic depletion of the amygdala and insular cortex on the potentiation of odor by taste aversions.
TLDR
The results suggest that catecholamines are necessary in the insular cortex for the acquisition of taste and in the amygdala for the Acquisition of odor aversion in the potentiation of odor by taste aversion paradigm. Expand
Enhancement of Antibody Production by a Learning Paradigm
TLDR
The experiments described here show that production of serum antibody to a defined protein antigen can be elicited by classical Pavlovian conditioning in Wistar rats, demonstrating that the immune system can be stimulated to produce apparently normal antibody responses by a simple behavioral paradigm. Expand
Cortical substrates of taste aversion learning: involvement of dorsolateral amygdaloid nuclei and temporal neocortex in taste aversion learning.
TLDR
Results indicate that destruction of the dorsolateral amygdaloid nuclei and/or the temporal neocortices may produce CTA learning deficits by affecting olfactory, gustatory, and/ or gastrointestinal processing in various portions of the forebrain. Expand
Conditioned Enhancement of Antibody Production Using Antigen as the Unconditioned Stimulus
TLDR
A classically conditioned enhancement of anti-KLH antibody titers was observed when conditioned mice were reexposed to the CS in the context of reexposure to a minimally immunogenic dose of that same antigen. Expand
Behaviorally Conditioned Immunosuppression
An illness-induced taste aversion was conditioned in rats by pairing saccharin with cyclophosphamide, an immunosuppressive agent. Three days after conditioning, all animals were injected with sheepExpand
Contrasting effects of centromedial and basolateral amygdaloid lesions on stress-related responses in the rat
TLDR
Findings provide modest support for the view that the central and lateral regions of the amygdala play complementary roles in aversively motivated behaviors and in stress-related response patterns. Expand
Neural Mediation of Conditioned Food Aversions a
  • S. Kiefer
  • Psychology, Medicine
  • Annals of the New York Academy of Sciences
  • 1985
TLDR
The above discussion is only a brief review of what is known about the neural mediation of conditioned food aversions, and a theoretical approach that may be valuable in understanding brain function in conditioned food aversion data is Hughlings Jackson's hierarchical notions of nervous organization. Expand
...
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2
3
4
5
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