Conditionally replicating adenovirus expressing TIMP2 for ovarian cancer therapy.

@article{Yang2011ConditionallyRA,
  title={Conditionally replicating adenovirus expressing TIMP2 for ovarian cancer therapy.},
  author={Sherry W. Yang and James J. Cody and Angel A. Rivera and Reinhard Waehler and Minghui Wang and Kristopher J. Kimball and Ronald A. Alvarez and Gene P. Siegal and Joanne T. Douglas and Selvarangan Ponnazhagan},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2011},
  volume={17 3},
  pages={538-49}
}
PURPOSE Current treatments for ovarian cancer have limited therapeutic outcomes due to advanced stage of the disease at diagnosis. Among new therapies, conditionally replicating adenoviruses (CRAds), designed to selectively lyse cancer cells, hold promise. In clinical trials, CRAds exhibited limited efficacy thus far. Second-generation CRAds are being developed to express a therapeutic protein to enhance antitumor efficacy. One attractive target in the tumor microenvironment is the matrix… CONTINUE READING

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