Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior

@article{Peters2005ConditionalTS,
  title={Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior},
  author={Howard Christian Peters and Hua Jun Hu and Olaf Pongs and Johan F Storm and Dirk Isbrandt},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={51-60}
}
In humans, mutations in the KCNQ2 or KCNQ3 potassium-channel genes are associated with an inherited epilepsy syndrome. We have studied the contribution of KCNQ/M-channels to the control of neuronal excitability by using transgenic mice that conditionally express dominant-negative KCNQ2 subunits in brain. We show that suppression of the neuronal M current in mice is associated with spontaneous seizures, behavioral hyperactivity and morphological changes in the hippocampus. Restriction of… CONTINUE READING
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