Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal.

@article{Benjamin1997ConditionalSO,
  title={Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal.},
  author={Laura E. Benjamin and E. Keshet},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 16},
  pages={8761-6}
}
We have recently shown that VEGF functions as a survival factor for newly formed vessels during developmental neovascularization, but is not required for maintenance of mature vessels. Reasoning that expanding tumors contain a significant fraction of newly formed and remodeling vessels, we examined whether abrupt withdrawal of VEGF will result in regression of preformed tumor vessels. Using a tetracycline-regulated VEGF expression system in xenografted C6 glioma cells, we showed that shutting… CONTINUE READING

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Benjamin and Keshet Proc

  • J. M. Isner, A. Pieczek, +9 authors 370–374. 8766 Medical Sciences
  • Natl. Acad. Sci. USA 94
  • 1997

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