Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation.

@article{Fan2015ConditionalSC,
  title={Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation.},
  author={Jinjiang Fan and Enrico Campioli and Andrew S Midzak and Martine Culty and Vassilios D. Papadopoulos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 23},
  pages={
          7261-6
        }
}
Translocator protein (TSPO) is a key member of the mitochondrial cholesterol transport complex in steroidogenic tissues. To assess the function of TSPO, we generated two lines of Cre-mediated Tspo conditional knockout (cKO) mice. First, gonadal somatic cell-targeting Amhr2-Cre mice were crossed with Tspo-floxed mice to obtain F1 Tspo Amhr2 cKO mice (Tspo(fl/fl);Amhr2-Cre(/+)). The unexpected Mendelian ratio of 4.4% cKO mice was confirmed by genotyping of 12.5-day-postcoitum (dpc) embryos. As… CONTINUE READING

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