Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation

@article{Fan2015ConditionalSC,
  title={Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation},
  author={J. Fan and E. Campioli and Andrew S Midzak and M. Culty and V. Papadopoulos},
  journal={Proceedings of the National Academy of Sciences},
  year={2015},
  volume={112},
  pages={7261 - 7266}
}
  • J. Fan, E. Campioli, +2 authors V. Papadopoulos
  • Published 2015
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • Significance Cholesterol-derived steroid hormones are critical mediators in development, reproduction, behavior, and stress response. Steroid biosynthesis occurs in hormone-dependent steroidogenic cells, which are defined by their ability to cleave cholesterol to pregnenolone in mitochondria, the adrenal cortex, and gonads. The rate-limiting step in steroid biosynthesis is the transport of cholesterol from intracellular stores into mitochondria. Translocator protein (TSPO) is a high-affinity… CONTINUE READING
    83 Citations
    Translocator protein (18 kDa): an update on its function in steroidogenesis
    • 46
    Regulation of Translocator Protein 18 kDa (TSPO) Expression in Rat and Human Male Germ Cells
    • G. Manku, M. Culty
    • Biology, Medicine
    • International journal of molecular sciences
    • 2016
    • 4
    TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis
    • 41
    • PDF
    Leydig cells: formation, function, and regulation†
    • 48
    • PDF

    References

    SHOWING 1-10 OF 44 REFERENCES
    Translocator protein/peripheral benzodiazepine receptor is not required for steroid hormone biosynthesis.
    • 170
    • PDF
    Peripheral Benzodiazepine Receptor/Translocator Protein Global Knock-out Mice Are Viable with No Effects on Steroid Hormone Biosynthesis*♦
    • 163
    • PDF
    Organelle plasticity and interactions in cholesterol transport and steroid biosynthesis
    • 62
    Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia.
    • 405
    • PDF
    Targeted Disruption of the Peripheral-type Benzodiazepine Receptor Gene Inhibits Steroidogenesis in the R2C Leydig Tumor Cell Line*
    • 211
    • PDF
    Developmental roles of the steroidogenic acute regulatory protein (StAR) as revealed by StAR knockout mice.
    • 205
    • PDF
    Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis
    • 367
    Peripheral-type benzodiazepine receptor-mediated action of steroidogenic acute regulatory protein on cholesterol entry into leydig cell mitochondria.
    • 202
    • PDF
    Identification of a dynamic mitochondrial protein complex driving cholesterol import, trafficking, and metabolism to steroid hormones.
    • 158
    • PDF
    Structural and functional evolution of the translocator protein (18 kDa).
    • 85