Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation

  title={Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation},
  author={J. Fan and E. Campioli and Andrew S Midzak and M. Culty and V. Papadopoulos},
  journal={Proceedings of the National Academy of Sciences},
  pages={7261 - 7266}
  • J. Fan, E. Campioli, +2 authors V. Papadopoulos
  • Published 2015
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • Significance Cholesterol-derived steroid hormones are critical mediators in development, reproduction, behavior, and stress response. Steroid biosynthesis occurs in hormone-dependent steroidogenic cells, which are defined by their ability to cleave cholesterol to pregnenolone in mitochondria, the adrenal cortex, and gonads. The rate-limiting step in steroid biosynthesis is the transport of cholesterol from intracellular stores into mitochondria. Translocator protein (TSPO) is a high-affinity… CONTINUE READING
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