Conditional reduction of adult neurogenesis impairs bidirectional hippocampal synaptic plasticity.

@article{Massa2011ConditionalRO,
  title={Conditional reduction of adult neurogenesis impairs bidirectional hippocampal synaptic plasticity.},
  author={Federico Massa and Muriel Koehl and Theresa Wiesner and Noelle Grosjean and J. M. Revest and P V Piazza and Djoher Nora Abrous and Stephane Oliet},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 16},
  pages={
          6644-9
        }
}
Adult neurogenesis is a process by which the brain produces new neurons once development has ceased. Adult hippocampal neurogenesis has been linked to the relational processing of spatial information, a role attributed to the contribution of newborn neurons to long-term potentiation (LTP). However, whether newborn neurons also influence long-term depression (LTD), and how synaptic transmission and plasticity are affected as they incorporate their network, remain to be determined. To address… CONTINUE READING
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