Conditional overexpression of TGF-β1 disrupts mouse salivary gland development and function

@article{Hall2010ConditionalOO,
  title={Conditional overexpression of TGF-β1 disrupts mouse salivary gland development and function},
  author={Bradford E. Hall and Changyu Zheng and William D. Swaim and Andrew San Aung Cho and Chandrasekharam N. Nagineni and Michael A. Eckhaus and Kathleen Corey Flanders and Indu S Ambudkar and B J Baum and Ashok B. Kulkarni},
  journal={Laboratory Investigation},
  year={2010},
  volume={90},
  pages={543-555}
}
Transforming growth factor-β (TGF-β) signaling is known to affect salivary gland physiology by influencing branching morphogenesis, regulating ECM deposition, and controlling immune homeostasis. To study the role of TGF-β1 in the salivary gland, we created a transgenic mouse (β1glo) that conditionally overexpresses active TGF-β1 upon genomic recombination by Cre recombinase. β1glo mice were bred with an MMTV (mouse mammary tumor virus)-Cre (MC) transgenic line that expresses the Cre recombinase… CONTINUE READING
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