Conditional modulation of spike-timing-dependent plasticity for olfactory learning

@article{Cassenaer2012ConditionalMO,
  title={Conditional modulation of spike-timing-dependent plasticity for olfactory learning},
  author={Stijn Cassenaer and Gilles Laurent},
  journal={Nature},
  year={2012},
  volume={482},
  pages={47-52}
}
Mushroom bodies are a well-known site for associative learning in insects. Yet the precise mechanisms that underlie plasticity there and ensure their specificity remain elusive. In locusts, the synapses between the intrinsic mushroom body neurons and their postsynaptic targets obey a Hebbian spike-timing-dependent plasticity (STDP) rule. Although this property homeostatically regulates the timing of mushroom body output, its potential role in associative learning is unknown. Here we show in… CONTINUE READING
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