Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption.

  title={Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption.},
  author={Abhisek Ghosal and Nils Lambrecht and Sandeep B. Subramanya and Rubina L Kapadia and Hamid Said},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={304 1},
The Slc5a6 gene expresses a plasma membrane protein involved in the transport of the water-soluble vitamin biotin; the transporter is commonly referred to as the sodium-dependent multivitamin transporter (SMVT) because it also transports pantothenic acid and lipoic acid. The relative contribution of the SMVT system toward carrier-mediated biotin uptake in the native intestine in vivo has not been established. We used a Cre/lox technology to generate an intestine-specific (conditional) SMVT… CONTINUE READING


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