• Corpus ID: 245502881

Conditional inference in cis-Mendelian randomization using weak genetic factors

  title={Conditional inference in cis-Mendelian randomization using weak genetic factors},
  author={Ashish Patel and Dipender Gill and Paul J Newcombe and Stephen Burgess},
Mendelian randomization is a widely-used method to estimate the unconfounded effect of an exposure on an outcome by using genetic variants as instrumental variables. Mendelian randomization analyses which use variants from a single genetic region (cisMR) have gained popularity for being an economical way to provide supporting evidence for drug target validation. This paper proposes methods for cis-MR inference which use the explanatory power of many correlated variants to make valid inferences… 

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