Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene.

  title={Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene.},
  author={Peter S Levitt and Houchun Liu and Charlene M Manning and Robert Samuel Weiss},
  volume={86 2},
The Hus1 cell cycle checkpoint protein plays a central role in genome maintenance by mediating cellular responses to DNA damage and replication stress. Targeted deletion of mouse Hus1 results in spontaneous chromosomal abnormalities and embryonic lethality. To study the physiological impact of Hus1 deficiency in adult mice, we generated a conditional Hus1 allele, Hus1(flox), in which exons two and three are flanked by loxP sites. Cre-mediated excision of the loxP-flanked region produces Hus1… CONTINUE READING
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