Conditional inactivation of Myc impairs development of the exocrine pancreas.

@article{Nakhai2008ConditionalIO,
  title={Conditional inactivation of Myc impairs development of the exocrine pancreas.},
  author={Hassan Nakhai and Jens T. Siveke and Lidia Mendoza-Torres and Roland M Schmid},
  journal={Development},
  year={2008},
  volume={135 19},
  pages={3191-6}
}
Recent studies have shown that Wnt/beta-catenin signaling is essential for development of the exocrine pancreas, but the role of beta-catenin-dependent target genes such as Myc during pancreatic development is not well known. Here, we show that tissue-specific deletion of Myc causes a slightly accelerated differentiation of pancreatic epithelial cells into endocrine cells and perturbs the proliferation of pancreatic progenitors and acinar precursor cells during early development, resulting in a… CONTINUE READING