Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning.

@article{Verheyden2005ConditionalIO,
  title={Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning.},
  author={Jamie M. Verheyden and Mark B Lewandoski and Chu-Xia Deng and Brian D Harfe and Xin Sun},
  journal={Development},
  year={2005},
  volume={132 19},
  pages={4235-45}
}
Previous studies have implicated fibroblast growth factor receptor 1 (FGFR1) in limb development. However, the precise nature and complexity of its role have not been defined. Here, we dissect Fgfr1 function in mouse limb by conditional inactivation of Fgfr1 using two different Cre recombinase-expressing lines. Use of the T (brachyury)-cre line led to Fgfr1 inactivation in all limb bud mesenchyme (LBM) cells during limb initiation. This mutant reveals FGFR1 function in two phases of limb… CONTINUE READING

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