Conditional gene targeting in mouse high endothelial venules.

@article{Kawashima2009ConditionalGT,
  title={Conditional gene targeting in mouse high endothelial venules.},
  author={Hiroto Kawashima and Jotaro Hirakawa and Yuki Tobisawa and Minoru Fukuda and Yumiko Saga},
  journal={Journal of immunology},
  year={2009},
  volume={182 9},
  pages={
          5461-8
        }
}
High endothelial venules (HEVs) are specialized blood vessels of secondary lymphoid organs composed of endothelial cells with a characteristic cuboidal morphology. Lymphocytes selectively adhere to and migrate across HEVs to initiate immune responses. In this study, we established a novel transgenic mouse line expressing Cre recombinase under the transcriptional control of the gene encoding HEV-expressed sulfotransferase, N-acetylglucosamine-6-O-sulfotransferase 2 (GlcNAc6ST-2), using bacterial… CONTINUE READING
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