Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration.

Abstract

Loss of presenilin function in adult mouse brains causes memory loss and age-related neurodegeneration. Since presenilin possesses gamma-secretase-dependent and -independent activities, it remains unknown which activity is required for presenilin-dependent memory formation and neuronal survival. To address this question, we generated postnatal forebrain… (More)
DOI: 10.1523/JNEUROSCI.1320-09.2009

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@article{Tabuchi2009ConditionalFI, title={Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration.}, author={K. Tabuchi and Guiquan Chen and Thomas C. S{\"u}dhof and Jie Shen}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={2009}, volume={29 22}, pages={7290-301} }