Conditional forebrain deletion of the L-type calcium channel Ca V 1.2 disrupts remote spatial memories in mice.

@article{White2008ConditionalFD,
  title={Conditional forebrain deletion of the L-type calcium channel Ca V 1.2 disrupts remote spatial memories in mice.},
  author={Jessica A White and Brandon C McKinney and Manorama C. John and Patricia A. Powers and Timothy J Kamp and Geoffrey G. Murphy},
  journal={Learning & memory},
  year={2008},
  volume={15 1},
  pages={1-5}
}
To determine whether L-type voltage-gated calcium channels (L-VGCCs) are required for remote memory consolidation, we generated conditional knockout mice in which the L-VGCC isoform Ca(V)1.2 was postnatally deleted in the hippocampus and cortex. In the Morris water maze, both Ca(V)1.2 conditional knockout mice (Ca(V)1.2(cKO)) and control littermates displayed a marked decrease in escape latencies and performed equally well on probe trials administered during training. In distinct contrast to… CONTINUE READING

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