Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure.

@article{Gotthardt2003ConditionalEO,
  title={Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure.},
  author={Michael Gotthardt and Robert Hammer and Norbert H{\"u}bner and Jan Monti and Christian C. Witt and Mark Malcolm McNabb and J. A. Richardson and Henk L Granzier and Siegfried Labeit and Joachim Herz},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 8},
  pages={
          6059-65
        }
}
Titin is a giant protein responsible for muscle elasticity and provides a scaffold for several sarcomeric proteins, including the novel titin-binding protein MURF-1, which binds near the titin M-line region. Another unique feature of titin is the presence of a serine/threonine kinase-like domain at the edge of the M-line region of the sarcomere, for which no physiological catalytic function has yet been shown. To investigate the role(s) of the titin M-line segment, we have conditionally deleted… CONTINUE READING
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