Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice

@article{Redfern1999ConditionalEA,
  title={Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice},
  author={Charles H. Redfern and Peter Coward and Michael Y. Degtyarev and Elena K. Lee and Andrew T. Kwa and Lothar Hennighausen and Hermann Bujard and Glenn I. Fishman and Bruce R. Conklin},
  journal={Nature Biotechnology},
  year={1999},
  volume={17},
  pages={165-169}
}
To control G protein signaling in vivo, we have modified G protein–coupled receptors to respond exclusively to synthetic small molecule agonists and not to their natural agonist(s). These engineered receptors are designated RASSLs (receptor activated solely by a synthetic ligand). A prototype RASSL (Ro1) based on the Gi–coupled κ opioid receptor was… CONTINUE READING