Conditional dominant mutations in the Caenorhabditis elegans gene act-2 identify cytoplasmic and muscle roles for a redundant actin isoform.

@article{Willis2006ConditionalDM,
  title={Conditional dominant mutations in the Caenorhabditis elegans gene act-2 identify cytoplasmic and muscle roles for a redundant actin isoform.},
  author={John H. Willis and Edwin Munro and Rebecca Lyczak and Bruce Bowerman},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 3},
  pages={
          1051-64
        }
}
Animal genomes each encode multiple highly conserved actin isoforms that polymerize to form the microfilament cytoskeleton. Previous studies of vertebrates and invertebrates have shown that many actin isoforms are restricted to either nonmuscle (cytoplasmic) functions, or to myofibril force generation in muscle cells. We have identified two temperature-sensitive and semidominant embryonic-lethal Caenorhabditis elegans mutants, each with a single mis-sense mutation in act-2, one of five C… CONTINUE READING

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