Conditional discrimination learning in rats with global ischaemic brain damage.

@article{Modo2000ConditionalDL,
  title={Conditional discrimination learning in rats with global ischaemic brain damage.},
  author={Michel Modo and Peter Sowinski and Helen Hodges},
  journal={Behavioural brain research},
  year={2000},
  volume={111 1-2},
  pages={213-21}
}
Hippocampal cell loss was induced by the four-vessel occlusion (4VO) method, a model of global ischaemia. Global ischaemia for 15 min induced a selective damage to the CA1 subfield. Occlusion for 25 min produced a larger cell loss within the CA1 and more variably the CA2, CA3, the striatum and cortex. Ischaemic and sham control groups were assessed on two conditional discrimination tasks (presenting the conditional cues either in the choice arms or the start arm) and two spatial tasks (water… CONTINUE READING
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