Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells.

@article{Swamynathan2007ConditionalDO,
  title={Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells.},
  author={Shivalingappa K. Swamynathan and Jonathan P. Katz and Klaus H. Kaestner and Ruth Ashery-Padan and Mary Alice Crawford and Joram Piatigorsky},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 1},
  pages={182-94}
}
The Krüppel-like transcription factor KLF4 is among the most highly expressed transcription factors in the mouse cornea (B. Norman, J. Davis, and J. Piatigorsky, Investig. Ophthalmol. Vis. Sci. 45:429-440, 2004). Here, we deleted the Klf4 gene selectively in the surface ectoderm-derived structures of the eye (cornea, conjunctiva, eyelids, and lens) by mating Klf4-LoxP mice (J. P. Katz, N. Perreault, B. G. Goldstein, C. S. Lee, P. A. Labosky, V. W. Yang, and K. H. Kaestner, Development 129:2619… CONTINUE READING

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