Conditional deletion of beta-catenin mediated by Amhr2cre in mice causes female infertility.

Abstract

Follicle-stimulating hormone (FSH) regulation of aromatase gene expression in vitro requires the transcriptional coactivator beta-catenin. To ascertain the physiological significance of beta-catenin in granulosa cells during folliculogenesis, mice homozygous for floxed alleles of beta-catenin were intercrossed with Amhr2cre mice. Conditional deletion of… (More)
DOI: 10.1095/biolreprod.108.072280

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