Conditional deletion of Stat3 promotes neurogenesis and inhibits astrogliogenesis in neural stem cells.

@article{Cao2010ConditionalDO,
  title={Conditional deletion of Stat3 promotes neurogenesis and inhibits astrogliogenesis in neural stem cells.},
  author={Fang Cao and Ryuji Hata and Pengxiang Zhu and Koh-ichi Nakashiro and Masahiro Sakanaka},
  journal={Biochemical and biophysical research communications},
  year={2010},
  volume={394 3},
  pages={843-7}
}
Although signal transducer and activator of transcription 3 (Stat3) plays crucial roles in the determination of neural stem cell (NSC) fate, Stat3 has multiple roles in NSC function. Moreover, Stat3 plays important roles in neuronal survival and tumorigenesis. To investigate the overall effects of Stat3 on NSC fate, NSC were isolated from Stat3(flox/flox) mouse embryos (E14-15d), in which both Stat3 alleles are flanked by LoxP sites. Isolated NSC was inoculated with an adenovirus vector… CONTINUE READING