Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair.

@article{Tsuji2010ConditionalDO,
  title={Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair.},
  author={Kunikazu Tsuji and Karen Cox and Laura Gamer and Daniel Graf and Aris E Economides and Vicki Rosen},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2010},
  volume={28 3},
  pages={384-9}
}
While the osteoinductive activity of recombinant bone morphogenetic protein 7 (BMP7) is well established, evaluation of the role of endogenous BMP7 in bone formation and fracture healing has been hampered by perinatal lethality in BMP7 knockout mice. Here we employ conditional deletion of BMP7 from the embryonic limb prior to the onset of skeletogenesis to create limb bones lacking BMP7. We find that the absence of locally produced BMP7 has no effect on postnatal limb growth, articular… CONTINUE READING

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