Conditional defect in mRNA 3' end processing caused by a mutation in the gene for poly(A) polymerase.

@article{Patel1992ConditionalDI,
  title={Conditional defect in mRNA 3' end processing caused by a mutation in the gene for poly(A) polymerase.},
  author={Dr. Mukesh R. Patel and James Scott Butler},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 7},
  pages={
          3297-304
        }
}
Maturation of most eukaryotic mRNA 3' ends requires endonucleolytic cleavage and polyadenylation of precursor mRNAs. To further understand the mechanism and function of mRNA 3' end processing, we identified a temperature-sensitive mutant of Saccharomyces cerevisiae defective for polyadenylation. Genetic analysis showed that the polyadenylation defect and the temperature sensitivity for growth result from a single mutation. Biochemical analysis of extracts from this mutant shows that the… CONTINUE READING
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