Conditional control of alternative splicing through light-triggered splice-switching oligonucleotides.


The spliceosome machinery is composed of several proteins and multiple small RNA molecules that are involved in gene regulation through the removal of introns from pre-mRNAs in order to assemble exon-based mRNA containing protein-coding sequences. Splice-switching oligonucleotides (SSOs) are genetic control elements that can be used to specifically control… (More)
DOI: 10.1021/jacs.5b00580

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