Conditional and replicative senescence in Escherichia coli.

  title={Conditional and replicative senescence in Escherichia coli.},
  author={{\AA}sa Fredriksson and Thomas Nystr{\"o}m},
  journal={Current opinion in microbiology},
  volume={9 6},
Analysis of the molecular mechanisms underlying the cellular degeneration of bacteria in stationary phase (known as conditional senescence) reveals interesting similarities with the aging process of higher organisms. These similarities include the role of self-inflicted oxidative damage and the importance of protein quality control systems in retarding senescence. In addition, recent data suggests that Escherichia coli cells display signs of replicative senescence, or loss of fitness, during… CONTINUE READING
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