Conditional ablation of macrophages halts progression of crescentic glomerulonephritis.

  title={Conditional ablation of macrophages halts progression of crescentic glomerulonephritis.},
  author={Jeremy S. Duffield and Peter G. Tipping and Tiina M. J. Kipari and J F Cailhier and Spike Clay and Richard C Lang and Joseph V. Bonventre and Jeremy Hughes},
  journal={The American journal of pathology},
  volume={167 5},
The presence of macrophages in inflamed glomeruli of rat kidney correlates with proliferation and apoptosis of resident glomerular mesangial cells. We assessed the contribution of inflammatory macrophages to progressive renal injury in murine crescentic glomerulonephritis (GN). Using a novel transgenic mouse (CD11b-DTR) in which tissue macrophages can be specifically and selectively ablated by minute injections of diphtheria toxin, we depleted renal inflammatory macrophages through days 15 and… CONTINUE READING


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