Conditional ablation of macrophages disrupts ovarian vasculature

  title={Conditional ablation of macrophages disrupts ovarian vasculature},
  author={Emily C Turner and Jeremy Hughes and Helen Wilson and Michael F. Clay and Katie J. L. Mylonas and Tiina M. J. Kipari and William Colin Duncan and Hamish M. Fraser},
Macrophages are the most abundant immune cell within the ovary. Their dynamic distribution throughout the ovarian cycle and heterogenic array of functions suggest the involvement in various ovarian processes, but their functional role has yet to be fully established. The aim was to induce conditional macrophage ablation to elucidate the putative role of macrophages in maintaining the integrity of ovarian vasculature. Using the CD11b-diphtheria toxin receptor (DTR) mouse, in which expression of… CONTINUE READING