Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection.

@article{Yanai2013ConditionalAO,
  title={Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection.},
  author={Hideyuki Yanai and Atsushi Matsuda and Jianbo An and Ryuji Koshiba and Junko Nishio and Hideo Negishi and Hiroaki Ikushima and Takashi Onoe and Hideki Ohdan and Nobuaki Yoshida and Tadatsugu Taniguchi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 51},
  pages={
          20699-704
        }
}
High-mobility group box 1 (HMGB1) is a DNA-binding protein abundantly expressed in the nucleus that has gained much attention for its regulation of immunity and inflammation. Despite this, whether and how HMGB1 contributes to protective and/or pathological responses in vivo is unclear. In this study, we constructed Hmgb1-floxed (Hmgb1(f)(/f)) mice to achieve the conditional inactivation of the gene in a cell- and tissue-specific manner by crossing these mice with an appropriate Cre recombinase… CONTINUE READING

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