Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation.

@article{Manuylov2011ConditionalAO,
  title={Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation.},
  author={Nikolay L. Manuylov and Bin Zhou and Qing Ma and Shawna C Fox and William T. Pu and Sergei G. Tevosian},
  journal={Developmental biology},
  year={2011},
  volume={353 2},
  pages={229-41}
}
Assembly of functioning testis and ovary requires a GATA4-FOG2 transcriptional complex. To define the separate roles for GATA4 and FOG2 proteins in sexual development of the testis we have ablated the corresponding genes in somatic gonadal cells. We have established that GATA4 is required for testis differentiation, for the expression of Dmrt1 gene, and for testis cord morphogenesis. While Sf1Cre-mediated excision of Gata4 permitted normal expression of most genes associated with embryonic… CONTINUE READING

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