Conditional Transgene Expression in Endothelial Cells

  title={Conditional Transgene Expression in Endothelial Cells},
  author={Renu Sarao and Daniel J. Dumont},
  journal={Transgenic Research},
The ability to tightly control transgene expression in vivo provides an opportunity to determine the role of certain gene products at different times during development and/or in response to different stimuli. We have characterized and evaluated a tetracycline-responsive endothelial-specific binary system during mouse development, by engineering several transgenic lines which drive the expression of a tetracycline- controlled transactivator (tTA) under the control of either the Tek or Tie… CONTINUE READING

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