Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cells.

@article{Mitsutake2005ConditionalBE,
  title={Conditional BRAFV600E expression induces DNA synthesis, apoptosis, dedifferentiation, and chromosomal instability in thyroid PCCL3 cells.},
  author={Norisato Mitsutake and Jeffrey A. Knauf and Shin Mitsutake and Cl{\'e}o O Mesa and Lei Zhang and James A. Fagin},
  journal={Cancer research},
  year={2005},
  volume={65 6},
  pages={2465-73}
}
The activating mutation BRAF(T1796A) is the most prevalent genetic alteration in papillary thyroid carcinomas (PTC). It is associated with advanced PTCs, suggesting that this oncoprotein confers thyroid cancers with more aggressive properties. BRAF(T1796A) is also observed in thyroid micropapillary carcinomas and may thus be an early event in tumor development. To explore its biological consequences, we established doxycycline-inducible BRAF(V600E)-expressing clonal lines derived from well… CONTINUE READING
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