Conditional Alpl Ablation Phenocopies Dental Defects of Hypophosphatasia.


Loss-of-function mutations in ALPL result in hypophosphatasia (HPP), an inborn error of metabolism that causes defective skeletal and dental mineralization. ALPL encodes tissue-nonspecific alkaline phosphatase, an enzyme expressed in bone, teeth, liver, and kidney that hydrolyzes the mineralization inhibitor inorganic pyrophosphate. As Alpl-null mice die… (More)
DOI: 10.1177/0022034516663633


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@article{Foster2017ConditionalAA, title={Conditional Alpl Ablation Phenocopies Dental Defects of Hypophosphatasia.}, author={Brian Foster and Patrick Kuss and Mayank Yadav and Tanja Kolli and Sonoko Narisawa and Lyudmila Lukashova and Esther Cory and R. L. Sah and Martha Joan Somerman and J. L. Mill{\'a}n}, journal={Journal of dental research}, year={2017}, volume={96 1}, pages={81-91} }