Conditional Activation of Fibroblast Growth Factor Receptor ( FGFR ) 1 , but not FGFR 2 , in Prostate Cancer Cells Leads to Increased Osteopontin Induction , Extracellular Signal-regulated Kinase Activation , and in Vivo Proliferation 1

Changes in the fibroblast growth factor receptor (FGFR) axis are often associated with prostate cancer (CaP) progression. We have used chemically induced dimerization (CID) to elucidate the individual contributions of FGFR1 and FGFR2 to tumor etiology. Novel CaP cell lines stably expressing CID/AP20187-inducible FGFR1 (iFGFR1) and iFGFR2 were made using the… CONTINUE READING