Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts.

@article{McCallum2016ConditionalAO,
  title={Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts.},
  author={Melissa L McCallum and Cindy A Pru and Yuichi Niikura and Siu-Pok Yee and John P. Lydon and John J. Peluso and James K. Pru},
  journal={Endocrinology},
  year={2016},
  volume={157 9},
  pages={3309-19}
}
Progesterone (P4) is essential for female fertility. The objective of this study was to evaluate the functional requirement of the nonclassical P4 receptor (PGR), PGR membrane component 1, in regulating female fertility. To achieve this goal, the Pgrmc1 gene was floxed by insertion of loxP sites on each side of exon 2. Pgrmc1 floxed (Pgrmc1(fl/fl)) mice were crossed with Pgr(cre) or Amhr2(cre) mice to delete Pgrmc1 (Pgrmc1(d/d)) from the female reproductive tract. A 6-month breeding trial… CONTINUE READING