Condition-specific deactivation of brain regions by 5-HT3 receptor antagonist Alosetron.

@article{Berman2002ConditionspecificDO,
  title={Condition-specific deactivation of brain regions by 5-HT3 receptor antagonist Alosetron.},
  author={Steven M. Berman and Lin Chang and Brandall Y. Suyenobu and Stuart W. G. Derbyshire and Jean Stains and Leah Fitzgerald and Mark A. Mandelkern and Lynn Hamm and Brent A. Vogt and Bruce D. Naliboff and Emeran A. Mayer},
  journal={Gastroenterology},
  year={2002},
  volume={123 4},
  pages={969-77}
}
BACKGROUND & AIMS The 5-HT3 receptor (5-HT3R) antagonist Alosetron (Alos) reduces the symptoms of female patients with diarrhea-predominant irritable bowel syndrome (IBS); yet, the mechanism(s) underlying this effect remains incompletely understood. We determined the effect of Alos on regional cerebral blood flow (rCBF) in the absence and presence of rectal… CONTINUE READING