Condensin-driven remodelling of X chromosome topology during dosage compensation.


The three-dimensional organization of a genome plays a critical role in regulating gene expression, yet little is known about the machinery and mechanisms that determine higher-order chromosome structure. Here we perform genome-wide chromosome conformation capture analysis, fluorescent in situ hybridization (FISH), and RNA-seq to obtain comprehensive three… (More)
DOI: 10.1038/nature14450


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@article{Crane2015CondensindrivenRO, title={Condensin-driven remodelling of X chromosome topology during dosage compensation.}, author={Emily Crane and Qian Bian and Rachel Patton McCord and Bryan R. Lajoie and Bayly S. Wheeler and Edward J. Ralston and Satoru Uzawa and Job Dekker and Barbara J Meyer}, journal={Nature}, year={2015}, volume={523 7559}, pages={240-4} }