Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells

@inproceedings{Fazzio2010CondensinCR,
  title={Condensin complexes regulate mitotic progression and interphase chromatin structure in embryonic stem cells},
  author={Thomas G Fazzio and Barbara Panning},
  booktitle={The Journal of cell biology},
  year={2010}
}
In an RNA interference screen interrogating regulators of mouse embryonic stem (ES) cell chromatin structure, we previously identified 62 genes required for ES cell viability. Among these 62 genes were Smc2 and -4, which are core components of the two mammalian condensin complexes. In this study, we show that for Smc2 and -4, as well as an additional 49 of the 62 genes, knockdown (KD) in somatic cells had minimal effects on proliferation or viability. Upon KD, Smc2 and -4 exhibited two… CONTINUE READING

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