Condensin and the Spindle Midzone Prevent Cytokinesis Failure Induced by Chromatin Bridges in C. elegans Embryos

@article{Bembenek2013CondensinAT,
  title={Condensin and the Spindle Midzone Prevent Cytokinesis Failure Induced by Chromatin Bridges in C. elegans Embryos},
  author={Joshua N Bembenek and Koen J. C. Verbrugghe and Jayshree Khanikar and Gy{\"o}rgyi Csankovszki and Raymond C. Chan},
  journal={Current Biology},
  year={2013},
  volume={23},
  pages={937-946}
}
BACKGROUND During cell division, chromosomes must clear the path of the cleavage furrow before the onset of cytokinesis. The abscission checkpoint in mammalian cells stabilizes the cleavage furrow in the presence of a chromatin obstruction. This provides time to resolve the obstruction before the cleavage furrow regresses or breaks the chromosomes, preventing aneuploidy or DNA damage. Two unanswered questions in the proposed mechanistic pathway of the abscission checkpoint concern factors… CONTINUE READING
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