Condensin and cohesin: more than chromosome compactor and glue

  title={Condensin and cohesin: more than chromosome compactor and glue},
  author={Kirsten A Hagstrom and Barbara J Meyer},
  journal={Nature Reviews Genetics},
Two related protein complexes, cohesin and condensin, are essential for separating identical copies of the genome into daughter cells during cell division. Cohesin glues replicated sister chromatids together until they split at anaphase, whereas condensin reorganizes chromosomes into their highly compact mitotic structure. Unexpectedly, mutations in the subunits of these complexes have been uncovered in genetic screens that target completely different processes. Exciting new evidence is… CONTINUE READING
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modern insights into classical questions

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