Condensin I binds chromatin early in prophase and displays a highly dynamic association with Drosophila mitotic chromosomes

@article{Oliveira2007CondensinIB,
  title={Condensin I binds chromatin early in prophase and displays a highly dynamic association with Drosophila mitotic chromosomes},
  author={Raquel Araujo de Oliveira and Stefan K. Heidmann and Claudio Enrique Sunkel},
  journal={Chromosoma},
  year={2007},
  volume={116},
  pages={259-274}
}
The condensed state of mitotic chromosomes is crucial for faithful genome segregation. Key factors implicated in the formation of mitotic chromosomes are the condensin I and II complexes. In Drosophila, condensin I appears to play a major role in mitotic chromosome organization. To analyze its dynamic behavior, we expressed Barren, a condensin I non-Structural Maintenance of Chromosomes subunit, as a fully functional enhanced green fluorescent protein (EGFP) fusion protein in the female and… CONTINUE READING